Despite his lack of formal training, he was awarded the Julius Rosenwald Fellowship in 1942, which led to a post with the FSA's photography unit in Washington, D.C., and consequently, the Office of War Information (OWI).
He also began working as a freelance photographer for Vogue and worked for Vogue for several years, establishing a distinct style that focused on the fluidity of models and attire rather than fixed postures. Parks relocated to Harlem and continued to photograph the city and people while engaged in the fashion industry. Parks' 1948 photograph article landed him a 20-year job as a staff photographer for LIFE magazine, where he photographed Black figures such as Kwame Ture, Malcolm X, and Muhammad Ali. Parks died of cancer in New York City on March 7, 2006.
Parks was the first Black artist to produce and direct a major Hollywood movie, The Learning Tree, based on his best-selling semiautobiographical novel.
Parks was awarded several accolades, including the National Medal of Arts in 1988. His works are now housed in the Art Institute of Chicago, the Metropolitan Museum of Art, and the Smithsonian National Museum of American History, among others.